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STUDIES ON THE BIOACTIVITY AND PHYCOCHEMISTRY OF MICROCYSTIS AERUGINOSA (CYANOPHYCOTA) FROM SINDH
M.N. KHALID1, MUSTAFA SHAMEEL1, V.U.
AHMAD2, SALEEM SHAHZAD3 AND S.M. LEGHARI4
Abstract: A toxic alga, Microcystis aeruginosa (KÜtzing) KÜtzing
was collected from ponds of Mancher Lake, near Thatta, Sindh
(Pakistan) during October 1994 and extracted in methanol. The crude
extract showed a strong antimicrobial activity against 14 bacterial
and 20 fungal species including 7 human-, 5 plant- pathogens and 8
saprophytes, but its cytotoxic activity against brine shrimp larvae
was non-significant. A variety of fatty acids (FAs) were detected
from the extract by GC-MS, including 7 saturated, 7 mono-, 4 di-, 7
tri- and 2 poly-unsaturated FAs. Oleic acid was present in the
higest proportion (30.5 %) followed by hexa- decatetraenoic and
pentadecylic acids (9-10 %). Palmitic acid was also present in
appreciable quantity (5.9 %). Furthermore cholesterol, stigmasterol,
β-sitosterol, phytol and sucrose have also been isolated from this
extract and chemically elucidated by a variety of spectroscopic
techniques.
1Department of Botany, University of Karachi, Karachi-75270,
Pakistan
2HEJ Research Institute of Chemistry, University of Karachi
3Department of Agriculture & Agribusiness Management,
University of Karachi
4Institute of Advance Research Studies in Chemical Sciences,
University of Sindh, Jamshoro-76080
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