Pak. J. Bot., 42(5): 3645-3649, 2010.

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DETERMINATION OF ANTIFUNGAL ACTIVITY OF CEDRUS DEODARA ROOT OIL AND ITS COMPOUNDS AGAINST CANDIDA ALBICANS AND ASPERGILLUS FUMIGATUS

REHANA PARVEEN¹, M. AHMED AZMI², R.M. TARIQ³, S. M. MAHMOOD⁴, MAZHAR HIJAZI⁵, SHAUKAT MAHMUD⁶ AND S.N.H. NAQVI⁷

Abstract: Studies have carried out to investigate the antifungal activity of Cedrus deodara root oil and compounds of this oil against Candida albicans and Aspergillus fumigatus. Cedrus deodara oil at the concentration of 150 μg/disc showed zone of inhibition against A. fumigatus but at the same concentration did not show any antifungal activity against C. albicans. Similarly compounds of C. deodara oil such as trans-atlantone and allo-himachalol also have not shown any antifungal activity, while himachalol at the concentration of 150 μg/disc showed zone of inhibition against A. fumigatus.

^1,6,7Institute of Pharmaceutical Sciences, Baqai Medical University, Karachi, Pakistan

²Department of Physiology, Baqai Medical University, Karachi, Pakistan

³M.A.H. Qadri, Biological Research Centre, University of Karachi, Karachi, Pakistan

⁴Department of Oncology, Agha Khan University Hospital, Karachi, Pakistan

⁵Department of Anatomy, Baqai Medical University, Karachi, Pakistan