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Bioactive Assessment of Selected Marine Red Algae
against Leishmania major and Chemical Constituents of
Osmundea pinnatifida
H. SABINA AND R. ALIYA*
Abstract:
The antileishmanial activities of the seven different species of red
algal extracts were evaluated against the promastigote form of
Leishmania major. The ethanol extracts of Osmundea pinnatifida
scored the highest activity with IC50 value 6.25 µg/mL
comparable to other algae such as Scinaia hatei with IC50
value 14.10 µg/mL, Melanothamnus afaqhusainii with IC50
value 32.6 µg/mL and Gracilaria corticata with IC50
value 37.5 µg/mL, which exhibited significant inhibitory effect
on the viability of Leishmania major. While other few species,
like Scinaia fascicularis, Centroceras clavulatum and
Botryocladia leptopoda were found to show good activity and gave
lethal effect In vitro, as conducted for the first time using the
Pakistani seaweeds. Current report describes the isolation and
structural elucidation of flavone Scutellarein 4'-methyl ether (1) being
a second report on the presence of flavone in algae and 4-Methoxy pyran
(2) from O. pinnatifida as reported for the first time
from the genus Osmundea.
Department of Botany,
University of Karachi, Karachi-75270, Pakistan
*Corresponding
author E-mail:
aliyaal@hotmail.com, Phone: + 92 21 4521974
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