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Pak. J. Bot., 46(1): 345-352, 2014. |
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Updated: 15-01-14 | ||||
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ANTIMICROBIAL AND SYNERGISTIC STUDIES OF RANUNCULUS MURICATUS L. AGAINST SOME INDIGENOUS BACTERIA
Sunniya Rasool1, Sikander Ali2* and Tahira A. Mughal1
Abstract: In the present study, antibacterial activity of the whole plant methanolic extract of Ranunculus muricatus L., was analyzed against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Bacillus pumilus, Salmonella typhimurium and Pseudomonas aeroginosa. Methanol was regarded as an excellent solvent for antimicrobial activity. It was observed as best bactericidal at a minimal inhibitory concentration (MIC) of 1-10 µg/ml against all the bacterial cultures viz. B. pumilus, B. subtilis, S. aureus, E. coli, P. aeroginosa and S. typhimurium. Synergistic antibacterial activity of methanolic extracts was tested with respect to solvent extract of leaves of Ricinus communis, Nerium oleander, Withania somnifera, whole plant of Heliotropiaum curassavicum and fruits of Citrullus colocynthis. Synergistical study revealed the best antibacterial activity against B. subtilis and B. pumilus at a level of 1 µg/ml except E. coli and S. aureus.
1Department of Botany, Lahore College for Women University (LCWU), Lahore, Pakistan 2Institute of Industrial Biotechnology (IIB), GC University Lahore, Pakistan *Corresponding author e-mail: alisbiotech@yahoo.com |
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