Pak. J. Bot., 47(3): 1195-1197, 2015.
LIPID PEROXIDATION, ANTIGLYCATION, CYTOTOXIC, PHYTOTOXIC, ANTIOXIDANT, ANTIPLATELET AND ANTIMICROBIAL ACTIVITIES OF AJUGA BRACTEOSA AGAINST VARIOUS PATHOGENS
NAJEEB UR REHMAN1,2, NAEEMA BEGUM1, LIAQAT ALI2, AHMED AL-HARRASI2,3, GHULAM ABBAS3, SAGHEER AHMAD1, ABDUL LATIF KHAN2, ZABTA KHAN SHINWARI4* AND JAVID HUSSAIN2,3*
Abstract:
This study
was carried out to evaluate the 
Brine
shrimp
lethality (cytotoxicity), antiglycation,
phytotoxicity,
antiplatelet, antifungal, and antibacterial
activities of Ajuga bracteosa. The n-hexane fraction of
Ajuga bracteosa was investigated for various biological activities
in vitro. Hexane extract showed promising phytotoxicity (100%) at
the highest dose only. Interestingly, n-hexane fraction showed
100% antiplatelet activity against AA (48 µg/mL) and PAF (15 µg/mL)
but it was
inactive against pathogenic bacteria and fungi used in the
antibacterial and antifungal assays. The antioxidant potential of
n-hexane fraction was evaluated by its potential to scaveng
superoxide anion radical, DPPH (2,2-diphenyl-1-picrylhydrazyl)
free radical, and the
lipid peroxidation assays.
The results showed that n-hexane fraction
exhibit
moderate activity against lipid peroxidation, DPPH, and superoxide
assays. In conclusion, the n-hexane fraction of A. Bracteosa
possess a strong biological role, which suggest the presence of
bioactive metabolites.
Key words: Ajuga bracteosa, Biological activities, Medicinal plant, Labiateae.
1Department of Chemistry, Kohat University of Science and Technology Kohat-26000, Khyber Pakhtunkhwa, Pakistan
2UoN Chair of Oman's Medicinal Plants and marine Natural products, University of Nizwa, Nizwa-616, Oman
3Department of Biological Sciences and Chemistry, College of Arts and Sciences, University of Nizwa, Nizwa-616, Oman
4Department of Biotechnology, Quaid-i-Azam University, Islamabad, Pakistan
*Corresponding author e-mail: shinwari2008@gmail.com & javidhej@yahoo.com