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BIOLOGICAL SCREENING OF IMPATIENS BICOLOR ROYLE

Muhammad nisar^1*, MUGHAL qayum^2*, MUHAMMAD RAZA shah³, HAMID LATIF SIDDIQUI⁴, Waqar Ahmad KALEEM² and M. ZIA-Ul-Haq⁵

Abstract: Crude methanolic extracts of Impatiens bicolor Royle as well as its different fraction namely n-hexane (A), dichloromethane (B), ethyl acetate (C), n-butanol (D) and aqueous (E) were tested In vitro for their insecticidal, cytotoxic and phytotoxic activities. Only n-hexane (A) fraction showed moderate insecticidal activity while ethyl acetate (C), n-butanol (D) and aqueous (E) fractions indicated low insecticidal activity. All fractions except n-butanol (D) indicated significant phytotoxicity. Cytotoxic results observed were also very low as compared to standard used and only dichloromethane (B) fraction showed cytotoxicity at higher dose while all other fractions as well as crude extract exhibited moderate to low activity in killing the tested brine shrimps.

¹Institute of Chemical Sciences, University of Peshawar, Peshawar-25120, NWFP, Pakistan

²Department of Pharmacy, University of Peshawar, Peshawar, 25120, Pakistan

³H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan

⁴Institute of Chemistry, University of the Punjab, Lahore-54590, Pakistan

⁵Department of Pharmacognosy, University of Karachi, Karachi-75270, Pakistan