PJB-2020-269
IN VITRO ANTIOXIDANT AND TOXICOLOGICAL STUDIES OF SELECTED SPECIES OF BAGH, AZAD JAMMU AND KASHMIR, PAKISTAN
Haadia Furman
Abstract
Ethanol, methanol and chloroform extracts of Gerbera gossypina, Cornus oblonga, Smilax aspera and Smilax glyciphylla were prepared to ascertain their biological potential. Initially, preliminary phytochemical tests were performed and then total phenolic and flavonoid contents were determined. Methanol leaves extract of G. gossypina (269.44 ± 3.27 mg GAE g-1 and 30.44 ± 1.94 mg QE g-1) and S. glyciphylla (265.84 ± 0.73 mg GAE g-1 and 25.44 ± 1.93 mg QE g-1) showed highest phenolic and flavonoid contents as well as the antioxidant activity. Artemia salina were used to observe cytotoxic potential and the highest toxicity was detected in the chloroform and methanol extracts of G. gossypina leaves (15.97 ppm and 20.88 ppm). Similarly, phytotoxic potential was also found to be highest in the methanol extracts of S. glyciphylla leaves (77 %). Hence, the selected botanicals represent new resource of therapeutic agents for treatment of various diseases.
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