PJB-2020-700
Relative efficacy and toxicity studies on three wild medicinal plants of Fabaceae: a pharmaceutical perspective
Urooj Khalil, Iram Fatima, Sobia Kanwal and Tariq Mahmood
Abstract
Naturally derived compounds with biological activities have positive effect on human health. In present study, ethanol, methanol and chloroform extracts of different parts of three plants viz. Dumasia villosa DC., Trifolium repens Linn. and Medicago laciniata var. laciniata belonging to family Fabaceae were prepared and various phytochemical tests were performed. Total phenolic and flavonoid contents were determined, and antioxidant activity was evaluated by DPPH scavenging assay, total reducing power assay and total antioxidant capacity. To determine toxicity potential of these extracts, radish seeds (phytotoxicity) and brine shrimp (cytotoxicity) assays were carried out. Methanol extract of D. villosa fruit revealed highest antioxidant and phytotoxic potential due to the presence of total phenolic and flavonoid contents while chloroform extracts of M. laciniata leaves and D. villosa fruit displayed highest cytotoxic potential. Hence, D. villosa fruit could be utilized in pharmaceutical industries against different ailments
To Cite this article:
Khalil, U., I. Fatima, S. Kanwal and T. Mahmood. 2022. Relative efficacy and toxicity studies on three wild medicinal plants of Fabaceae: a pharmaceutical perspective. Pak. J. Bot., 54(4): DOI: http://dx.doi.org/10.30848/PJB2022-4(34)
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