PJB-2021-45
In vitro anticancer, antioxidants, and phytotoxic efficacy of the Hedera helix and Moringa oleifera extracts
Khushnood Ur Rehman, Muhammad Hamayun, Zahid Ali Butt, Tabassum Yaseen, Sabir Hussain Shah and Sher Wali
Abstract
In this research work, key biological activities such as the anticancer, antioxidant, and phytotoxic potential of H. helix (common ivy) and M. oleifera (drumstick tree) were confirmed. For phytotoxic activity plant materials were used in (10, 20, and 40 mg) powder form. The phytotoxic results of these plants were very significant, with the value of P = 0.000289 which carried promising effects on the germination of the test plant Lactuca sativa. The outcomes of the antioxidant activity of the selected plants were very encouraging and significant with a value of P= 0.002333 in the ANOVA test and displayed a small IC50 value for scavenging DPPH, hence showing sufficient scavenging potential. Amongst the well-known fractions Ethyl acetate 16.14±0.259 μg/ml, and 21.55±0.158 μg/ml, Cr. Methanol extracts scavenged DPPH with 19.61±0.978 μg/ml and 26.65±0.149 μg/ml, for H. helix and M. oleifera respectively confirming strong antioxidant activities. The anti-tumor activity of DCM fractions restrained the cancer cell (Colon cancer cells: HT-29) development to 69.08%, and, 68.69%, with value of P = 0.000299 for Hedera helix and P = 5.1x 10-06 for M. oleifera.
To Cite this article:
Rehman, K.U., M. Hamayun, Z.A. Butt, T. Yaseen, S.H. Shah and S. Wali. 2022. In vitro anticancer, antioxidants, and phytotoxic efficacy of the Hedera helix and Moringa oleifera extracts. Pak. J. Bot., 54(5): DOI: http://dx.doi.org/10.30848/PJB2022-5(41)
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