PJB-2021-652
In-vivo pharmacognostic study of bark extract of Ehretia acuminata by using animal model
Hikmat Ullah Jana
Abstract
Ehretia acuminata, commonly known as “Puna†in Pakistan is a deciduous average to sizeable tree from Boraginaceae. The plant occasionally reaches 30 meters in stature and has about 0.9 meters bole (stock) width used in ecological, medicinal and agricultural sectors. The current study was conducted to assess the pharmacological potency of bark extracts of E. acuminata. The crude distilled water, ethanol and chloroform extracts signified a concentration reliant increase in intestinal mobility of the experimented animal and the plant delivered a methodical proof for its pharmacological usage as an antispasmodic drug. The Bark distilled water, Bark ethanol and Bark chloroform extracts revealed (11±1, 9±1 and 11±1) inhibition at (300 mg/kg). The distilled water, ethanol and chloroform extracts also showed the analgesic potential in present study and the results were concentration dependent. The Bark distilled water, Bark ethanol and Bark chloroform extracts revealed the (10±1, 16±1 and 11±1) analgesic potential at (300 mg/kg). The distilled water, ethanol and chloroform extracts also showed the muscle relaxant potential in this study and the results were concentration dependent. The Bark distilled water, Bark ethanol and Bark chloroform extracts revealed the (6±1, 5±1 and 5±1) at (300 mg/kg). While the distilled water, ethanol and chloroform extracts did not show acute toxic effects against the tested mice.
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