PJB-2023-214
Evaluation and estimation of diuretic activity of the linalyl acetate in the rats
FAIZA RAFIQUE
Abstract
This study was aimed to explore the diuretic activity of the linalyl acetate. Linalyl acetate is an essential oil, it is an integral phytoconstituent of various plants. In this study acute and chronic diuretic activities were explored by measuring the level of different electrolytes and pH were analyzed in the urine of experimental rats. Rats were divided into six groups. Different doses of LA including 25, 50 and 75 mg/kg were used in order to find its diuretic potential. Urine volume for acute diuretic activity was measured for 6 hours however for the chronic diuretic activity was measured for 6 days. Moreover, the underlying mechanism of the diuretic activity was also explored by comparing with atropine, L-NAME and indomethacin. The results were presented as mean ± standard error of the mean of 6 rats each group. The statistical analysis by using the Analysis of Variance (ANOVA). Results revealed that the LA 75 mg/kg dose showed comparable result as of furosemide. This study revealed the involvement of muscarinic receptors to produce diuresis on comparison with atropine with very little involvement of prostanoids and having no effect on NO pathway induced by indomethacin and L-NAME respectively. It is concluded that LA possess the anti-diuretic potential. Muscarinic receptors might be involved in producing diuretic effects.
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