PJB-2023-560
Analytical studies and biological activities of propolis oil from north Punjab, Pakistan
Shabana Islam, Shahida Shujaat, Erum Akbar Hussain, Zahida Parveen and Syed Tahir Ali
Abstract
Propolis is a resinous material prepared by honeybees, has an extensive range of biological properties, and is an important part of the herbal medicinal system. This is the first study to investigate the chemical composition and biological potential of oil extracted from brown propolis collected from the hives of Apis mellifera on the trees of Populus from Northern Punjab, Pakistan. The extraction of oil was carried out using the microwave oven. Forty five phytochemical constituents were identified by gas chromatography-mass spectrometry (GC-MS). Sesquiterpenoid (α-Eudesmol and (-)-β-Copaene) and sesquiterpenes including τ-Cadinol, L-Calamenene and α-Humulene, were the most prominent natural products. The results showed two unknown compounds (5%) which remained unidentified due to unavailability of data on NIST-2011. The volatile oil derived from brown propolis displayed remarkable efficacy in terms of its antioxidant (IC50 0.54 ± 0.07mg/mL), anti-inflammatory (IC50 51.0239± 0.01mg/mL), antitumor (against the HeLa-human cervical cancer cell line) (IC50 1.96± 1.52 mg/mL), antifungal against (A. niger (MIC > 3mg/mL), A. flavus (MIC > 5mg/mL) and antibacterial properties against (Bacillus mojavensis (MIC 0.421mg/mL), Staphylococcus aureus (MIC 0.501mg/mL), Pseudomonas aeruginosa (MIC 0.829mg/mL), Escherichia coli (MIC 0.943mg/mL) and Salmonella typhimurium (MIC > 2mg/mL). Therefore, propolis oil is suggested as a potential therapeutic agent and can be used as a readily available indigenous source for treating microbial infections
To Cite this article:
Islam, S., S. Shujaat, E.A. Hussain, Z. Parveen and S.T. Ali. 2025. Analytical studies and biological activities of propolis oil from north Punjab, Pakistan. Pak. J. Bot., 57(2): DOI: http://dx.doi.org/10.30848/PJB2025-2(32)
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