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Abstract

This study aimed to explore the pharmacological potential of Phoenix dactylifera L. seeds. The acetic acid-induced writhing test was employed to assess analgesic activity, the carrageenin-induced edema test was used to evaluate anti-inflammatory potential, and the charcoal-induced spasm test was conducted to examine antispasmodic activity. The organic fractions of P dactylifera L. seeds exhibited significant dose-dependent suppression of pain in the acetic acid-induced writhing test at 150 and 300 mg/kg, surpassing standard medications. The n-hexane partition of the seeds demonstrated a 53.7% reduction in writhing response compared to the traditional medication's 66.67%. The seed’s methanolic and chloroform extracts exhibited notable pain suppression (51.8% and 44.4%, respectively). Similarly, the n-hexane partition of commercial seeds displayed the highest percentage inhibition (62.9%), followed by chloroform (58.8%) and methanol (56.48%). In the carrageenin-induced paw edema test, the methanol extract of Ajwa original seeds showed the highest reduction (71%) compared to the standard drug (79.4%) after 3 hours at a dosage of 300 mg/kg. The chloroform and n-hexane extracts also demonstrated significant reductions (64.6% and 62.5%, respectively). The methanol partition of market seeds exhibited the highest reduction (71.4%), followed by n-hexane (59.2%) and chloroform (35.1%). Additionally, the methanol extract of Ajwa original seeds showed the highest inhibitory percentage (65.5%) in the charcoal-induced spasm test at 300 mg/kg, followed by n-hexane (61.8%) and chloroform (49%). In the market seeds, the methanol partition demonstrated the highest inhibition (67.7%), followed by n-hexane (62.5%) and chloroform (52.39%). Phytochemical analysis confirmed the presence of flavonoids, glycosides, sugars, and lipids. The methanol extract contained the highest amount of sugar, while flavonoids and lipids were predominant in the chloroform and n-hexane extracts, respectively. These findings highlight the nutritive and curative properties of Phoenix dactylifera L. seeds as a valuable source of natural products for treating diseases, further study is recommended to isolate potential compounds and check it on clinical trials

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