PJB-2023-623
Pharmacognostical And Pharmacological Evaluation of Medicinally Important Fingerhuthia Africana. Lehm.
Rehnaz Sajid
Abstract
Many medicinal plants have been utilized for centuries despite the lack of scientific evidence of their therapeutic effects. This study evaluated the phytochemical and dual biological profiling, namely, antimicrobial and cytotoxic properties of Fingerhuthia africana. The extract of the plant was subjected to qualitative phytochemical screening using the established protocol and disc diffusion and microdilution assays were used for the antibacterial and antifungal activities. The qualitative Phytochemical analysis illustrated that methanol extracts of F. africana were rich in different phytochemicals including Carbohydrates, terpenoids, flavonoids, fats oil, glycosides, phenols and tannins. and absence of alkaloids and steroids. The result of antibacterial activity of methanolic extract of F. africana showed that the highest zone of inhibition (28.0±1.00 mm) was measured against Escherichia coli at the maximum (300 mg/ml) extract concentration. followed by P. aeruginosa and S. aureus (27.3±1.52 mm), (27.6±1.52mm) and the lowest zone of inhibition (6.66±2.08 mm) by E. coli at minimum (100 mg/ml) extract concentration. The results of antifungal activity revealed that the methanolic extract of F. africana showed significant antifungal activity (18.66±1.52 mm) against Aspergillus flavus at the maximum (300 mg/ml) extract concentration. followed by A. terreus and F. oquiseti (13.33±1.52mm) (16.0±1.00mm) and lowest antifungal activity against Aspergillus flavus (4.00±1.732 mm) at minimum (100 mg/ml) extract concentration. The results of cytotoxic potential to kill brine shrimp napulii. 10 mg/ml, 100 mg/ml and 1000 mg/ml of dose of methanolic extract showed (6.67%) (6.67%) and (33.34%). cytotoxic potential to kill brine shrimp napulii. 1000 mg/ml of dose of methanolic extract showed the highest (33.34%) death rate of brine shrimps. 10 mg/ml of methanolic extract validated the lowest mortality rate (6.67 %). The results showed that F. africana had a substantial potential for pharmacological activity, in general. The analysis that was suggested provided a way to extract the bioactive elements and will aid in the development of new drugs that have fewer side effects. The findings clearly demonstrate that F. africana has the capacity to treat a variety of diseases due to its effectiveness against a range of ailments.
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