PJB-2024-49
In vitro anti-inflammatory, anticancer and antimicrobial activity of Annona reticulata (red custard apple) peel and pulp extracts – A comparative study &l
Kalist Shagirtha
Abstract
Abstract
Recently, research has focused on the anti-inflammatory, anticancer and antibacterial activities of natural compounds as potential therapeutic agents. Annona reticulata is a source for both industrial and medicinal products. It has a therapeutic effect, including anthelmintic, antipyretic, anti-inflammatory, cytotoxic and wound-healing properties. Phytochemicals such flavonoids, phenols, alkaloids, steroids, tannins, and glycosides are widely distributed in it. This study compared the anti-inflammatory, antibacterial, and anticancer properties of Annona reticulata (red custard apple) fruit pulp and peel extracts of fruits. The anti-inflammatory activity of pulp and peel extract of Annona reticulata determined by inhibition of albumin denaturation and membrane lysis assay. The anticancer activity was tested against the MCF-7 using the MTT assays. The antibacterial activity against Proteus mirabilis and Pseudomonas aeruginosa was studied by disc diffusion method. The findings showed that the fruit pulp extract had more potential for anti-inflammatory, antibacterial, and anticancer action than the peel extract chosen for testing. Based on our findings, we suggested that Annona reticulata pulp would be a source of components for the culinary and pharmaceutical industries.
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