PJB-2024-122
Exploring the Therapeutic Potential of Amberboa ramosa: A Review of Secondary Metabolites and Their Applications in Dermatology, Alzheimer's Disease, and Diabetes
Hafsa Iqbal
Abstract
Amberboa ramosa, a member of the Compositae family, exhibits phytochemical and therapeutic potential in the fields of pharmacology, dermatology, Alzheimer's disease, and diabetes. Phytochemical components such as flavonoids, steroids, steroidal glycosides, and a chloroform-soluble fraction have been identified. Its bioactive compounds have demonstrated inhibitory effects on key enzymes involved in melanin production, cholinesterase activity, and butyrylcholinesterase, making it relevant to these health conditions. This plant's compounds have shown strong to moderate inhibitory activity against tyrosinase, making them valuable for treating dermatological conditions associated with hyperpigmentation and skin whitening. In Alzheimer's disease, where cholinergic neurotransmission dysfunction plays a role, the cholinesterase inhibitors from Amberboa ramosa could serve as promising leads for future therapeutic development. For diabetes, the plant's ability to inhibit butyrylcholinesterase, a factor associated with Type II diabetes, is significant. As the prevalence of diabetes rises globally, the search for natural antidiabetic compounds gains importance. While Amberboa ramosa's bioactive components have shown promise, further research is needed to understand their mechanisms, safety, and efficacy for medical applications.
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