PJB-2024-359
DETERMINATION OF ANTIBACTERIAL EFFICACY OF FAGONIA ARABICA AGAINST STAPHYLOCOCCUS SPP
Shawana Maqsood
Abstract
Fagonia arabica, a member of the Zygophyllaceae family, is a medicinal plant that grows in desert regions of the world, including Pakistan.Ayurveda indicated its use in a variety of forms. Linnaeus introduced the genus Fagonia in 1753 .Currently, the genus Fagonia has 35 species. A variety of plant compounds have been found throughout the genus, including sugars, flavonoids, glycosides, steroids, saponins, alkaloids, triterpenoids, amino acids, chlorides, sulfates, anthraquinones, cycloiodones, cyanogenic glycosides, and coumarins. This study examined the anti-bacterial potential of F. arabica to overcome the resistivity of organisms due to overuse of antibiotics. Methanol and chloropharm solvents used to extrac t phytocompounds of F.arabica whole plant. Antimicrobial activity against Staphylococcus aureus and Staphylococcus epidermidis was evaluated using well diffusion and microtitre plate method, protein leakage by bradfold method as well as antibiofilm activity also determined.The findings exposed that the studied bacterial spp (S.aureus and S.epidermidis) were sensitive to extracts. Of F.arabica. Methanolic extract exhibited sensitivity against both S.aureus and S.epidermidis while chloropharm extract only showed sensitivity against S.epidermidis with minimum inhibitory concentration between 2.5 and 20 mg/ml. Mode of action determined satisfactory antibiofilm activity and increase cons. of protein leakage. According to the findings of this study, the whole part of F.arabica could be considered a possible source of natural antibiotics as well as a valuable source of antibiofilm agent against bacteria that cause skin infections like acne vulgaris.
Keywords: Antimicrobial, biofilm, Protein leakage, F. arabica
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