PJB-2024-614
YUVIANTI DWI FRANYOTO
Abstract
Inflammation plays a pivotal role in the pathologies of various diseases. Inhibiting the expression of cytokines involved in inflammation is crucial for the development of anti-inflammatory agents. Murraya koenigii (curry tree) is a medicinal plant traditionally used to treat inflammation. However, the effect of M. koenigii leaf extract (MKE) on pro-inflammatory cytokines has not been published. This study aimed to assess the anti-inflammatory activity of MKE and investigate its effect on pro-inflammatory cytokines. The leaves of M. koenigii were extracted in ethanol (90%), and the chemical constituents were analyzed using liquid chromatography coupled with high-resolution mass spectroscopy. The extract was evaluated in carrageenan-induced paw edema rat models at doses of 100, 200, and 400 mg/kg. The levels of inflammatory cytokines, interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNFα) were measured using enzyme-linked immunosorbent assay. The results indicated that MKE at 100, 200, and 400 mg/kg inhibited inflammation (24.55%, 34.21%, and 43.61%, respectively). The levels of TNFα, IL-1β, and IL-6 were also decreased compared with the solvent-treated group. MKE demonstrated anti-inflammatory activity in carrageenan-induced rat paw edema by reducing the levels of inflammatory cytokines (IL-1β, IL-6, and TNFα). This study provided scientific data regarding the anti-inflammatory activity of M. koenigii.
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