Paper Details

PJB-2025-205

Anticancer potential of Cryptolepis buchananii plant bark extract: cytotoxicity and expression of VEGFR2 and SOAT1 genes

 

Wagma Hassan, Ishaq Khan, Muhammad Nabi, Waseem Ahmed, Rafiq Ahmad, Amjad Hassan, Syed Afzal Shah and Sabaz Ali Khan
Abstract

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This review focuses on rare, endemic, and wild species of the genus Ribes in Central Asia and Kazakhstan. It highlights species listed in national and international Red Lists and discusses the primary threats they face, such as habitat degradation, climate change, and anthropogenic pressure. The review provides details on species distribution, ecological characteristics, and altitudinal ranges, emphasizing the high degree of habitat fragmentation and narrow ecological specialization of most species. The importance of regional monitoring, comprehensive floristic studies, and genetic research is underscored. The review also explores current conservation techniques, including seed and vegetative propagation, In vitro micropropagation and cryopreservation. The limited development of protocols for most rare Ribes species is identified as a significant barrier to effective conservation efforts. It also considers integrated conservation strategies that combine In situ, Ex situ, and quasi In situ approaches. Emphasis is placed on the need for international cooperation, the creation of botanical databases, and the incorporation of biotechnological methods into conservation practices. Preserving Ribes biodiversity requires a multifaceted approach, combining scientific, technological, and legal solutions to ensure the long-term survival of these species

To Cite this article: Hassan, W., I. Khan, M. Nabi, W. Ahmed, R. Ahmad, A. Hassan, SA. Shah and S.A. Khan. 2026. Anticancer potential of Cryptolepis buchananii plant bark extract: cytotoxicity and expression of VEGFR2 and SOAT1 genes. Pak. J. Bot., 58(2): DOI: http://dx.doi.org/10.30848/PJB2026-2(16)
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