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Abstract

Multidrug resistance (MDR) bacterial infections are a growing global health concern. As a result, there is a growing need to discover effective antimicrobial agents from non-conventional sources. In recent years, Cyanobacteria have received significant attention in basic and applied research due to their ability to produce wide range of bioactive metabolites with antimicrobial properties. This study aimed to isolate and characterize Cyanobacterial isolates from fresh water streams of Haripur city of Khyber Pakhtunkhwa, Pakistan, and to evaluate their antimicrobial potential. A total of 10 water samples were collected, from which 9 cyanobacterial isolates were cultured using BG-11 medium. Antimicrobial activity was assessed using agar well diffusion method against 4 pathogens, namely Pseudomonas aeruginosa, Bacillus spp., Staphylococcus aureus and Escherichia coli. Among the isolates, 9 exhibited antimicrobial activity against at least one of the tested pathogens. Based on morphological and biochemical characteristics, the isolates were tentatively identified at the generic level as Oscillatoria spp. (50%), Nostoc spp. (30%), and Microcystis spp., (20%). Although species level identification and chemical characterization were not performed, the observed antimicrobial activity suggests that freshwater cyanobacteria may serve as a potential source of bioactive compounds with therapeutic relevance

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