PJB-2015-235
CYTOTOXIC AND ANALGESIC POTENTIALS OF PAPAVER PAVONINUM FISCH & MEY.
MUHAMMAD IBRAR¹, MARYAM EHSAN¹, BARKATULLAH¹, KHAN BAHADAR MARWAT² AND SYEDA SARAH MUBARAK¹
Abstract
Ethanolic extract of whole plant of Papaver pavoninum was used to investigate its cytotoxic and analgesic potentials. Brine Shrimp Cytotoxic bioassay showed that 100 and 1000 µg/ml doses produced highly significant cytotoxicities causing 83.3±1.924% and 96.7±1.924% lethalities respectively, with LD50 value of 2.54μg/ml. The analgesic bioassay, using acetic acid induced writhing behavior in mice showed that all the three doses of the extract (50, 100 and 150 mg/kg) were highly effective and even more effective than the standard analgesic drug (Diclofenic Sodium), which reduced the number of writhes by 13.54%, while the three doses of the plant extract reduced the writhing by 36.91%, 57.01% and 68.39% respectively.
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