PJB-2018-232
The Potential Use of Folk Herbal Entities for the Remedy of Skin and Soft Tissues Pathogens
Murad Ali Khan
Abstract
Resistance to clinically used antibiotic is commonly reported against pathogens causing skin and soft tissue infections. To overcome the problem, the potential of the plants Carium carvi seeds and Curcuma longa used in folk medicine were tested against clinically isolated skin and soft tissues pathogens. Skin and soft tissue infection causing pathogens, Pseudomonas aerugenosa, Staphylococcu aureus, Staphylococcus epidermidis and Streptococcus pyogenes were collected from patients. The identification of isolated pathogens was made by microscopic studies followed by various biochemical tests. These pathogens were then treated against different extracts of the plants Carium carvi seeds and Curcuma longa used in folk medicine. Antibacterial activities of fractions were determined by using well diffusion assay and minimum inhibitory concentration (MIC). The results showed marked antibacterial activity of the chloroform and ethyl acetate extract of Carium carvi seeds while the chloroform extract of Curcuma longa showed promising results. Sensitivity of various extracts of the plant in a concentration dependent manner with significant MIC values was determined. Our findings showed that the extracts of Curcuma longa and C. carvi seeds possess strong antibacterial effects against clinically isolated skin and soft tissue pathogens.
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