PJB-2018-693
ANALGESIC AND ANTI-INFLAMMATORY ACTIVITIES OF AGARICUS CAMPESTRIS AND BALLOTA LIMBATA ON MICE
Imran Waheed
Abstract
Agaricus campestris (A. campestris) and Ballota limbata (B. limbata) have though been reported for a variety of pharmacological activities yet not investigated for analgesic and anti-inflammatory activities. Crude methanolic extract of A. campestris, in addition to crude extract and fractions of B. limbata were evaluated for their analgesic and anti-inflammatory effects in mice. Four groups of mice were treated with doses (300mg/kg and 500mg/kg) of A. campestris and B. limbata, aspirin (300mg/kg) and vehicle (0.5% normal saline). Analgesic activity was determined by acetic acid-induced writhing and anti-inflammatory activity by 1% formalin in right hind paw of mice. Aspirin (300mg/kg) was used as control. Crude extract of A. campestris showed significant analgesic activity at dose of 300mg/kg (P < 0.05) and 500mg/kg (P < 0.01). Similarly, crude extract and fractions of B. limbata showed highly significant (P < 0.01) analgesic activity on administration of both doses. Crude extracts of A. campestris and B. limbata as well as the fractions of later demonstrated highly pronounced (P < 0.01) anti-inflammatory activity at doses of 300mg/kg and 500mg/kg when compared to aspirin. Hence it is concluded that the extracts of A. campestris and B. limbata and fractions of later possesses analgesic as well as anti-inflammatory action.
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