PJB-2018-707
CANNABIS SATIVA MEDIATED SYNTHESIS OF GOLD NANOPARTICLES AND ITS PHARMACOGNOSTIC PROPERTIES
Safia Hameed
Abstract
Nanotechnology describes precision manufacturing of materials at Nano scale. Nanotechnology has vast range of applications such as Medicines, Electronics, Bio materials and Energy production. Nanotechnology is ecofriendly and cost effective. The present research work is green ecofriendly approach by using plant extract of cannabis sativa for the production of gold Nanoparticles. The appearance of ruby red colour from greenish is the primary indication of the formation of gold Nanoparticles. Cannabis sativa contain some active compounds which found to be responsible for the reduction of gold and convert it into a bioactive metal. The synthesized gold nanoparticles were characterized by UV-Vis spectra, SEM and FTIR. The UV spectra of aqueous medium containing gold Nanoparticles showed absorbance band at 551 nm. SEM analysis showed spherical morphology of synthesized AuNPs with an average particle size of 33 nm. Analysis of FTIR showed the existence of numerous functional groups accountable for the reduction of AuNPs. In vitro antimicrobial, cytotoxic, biocompatible and enzyme inhibition assays were performed. Notable antimicrobial activities are reported. Bioinspired Au nanoparticles were found effective against bacterial and fungal strains. MTT assay was performed to check the leishmanicidal activity against amastigotes (IC50: 171 ± 2.28 μg/ml) of Leishmania tropica. Brineshrimp lethality was also indicated by bioinspired Au nanoparticles. Furthermore, substantial protein kinase was noted.
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