PJB-2018-752
ANALGESIC AND ANTIINFLAMMATORY POTENTIAL OF MISOPATES ORONTIUM
MUHAMMAD AJAIB
Abstract
Abstract: In the current study in vitro analgesic and antiinflammatory potentials of ethanolic extracts of Misopates orontium (L.) Raf were evaluated in dose dependent manner as compared to the control and standard drugs. Analgesic activity was investigated by using hot plate, tail flicking/immersion methods, and formalin-induced paw licking in mice, whereas, antiinflammatory potential was investigated by using carrageenan-induced hind paw edema in albino rats. The doses of 100, 200, and 300 mg/kg concentrations were used. In hot plate method, the extract of 300 mg/kg showed significant results within the range of 22.4 ± 0.79 at 1.5 h, 26.6 ± 0.52 at 2 h, and 26.6 ± 0.51 at 2.5 h that was closed to the latency of pain as compared to the standard drug aspirin. Results indicate that in tail immersion method also the extract of 300 mg/kg was most effective and reduced latency of pain up to 7.2 ± 0.83 at 1.5 h, 8.6 ± 0.30 at 2 h, and 8.8 ± 0.35 at 2.5 h. In paw licking method, the standard drug used was aspirin, the most effective dose was 300 mg/kg at which the licking and biting was reduces within 30 minutes, i.e. 3 ± 0.58 at 10 min, 2 ± 0.51 at 20 min, and 1 ± 0.71 at 30 min. In antiinflammatory activity, three doses were also used at 100, 200, and 300 mg/kg concentration. In this activity expansion in paw volume was measured after carrageenan injection. Results indicated that after carrageenan injection the paw volume increased but after few intervals of time it again reduced i.e. 6.17 ± 0.15 at 2 h, 5.82 ± 0.15 at 3 h, and 5.53 ± 0.20 at 4 h the results were compared with standard drug diclofenac sodium and control group. This study suggested that the plant contained, both antiinflammatory and analgesic activities.
To Cite this article:
Download
