PJB-2018-824
Proteolysis in Archaea: special focus on Pyrobaculum calidifontis.
Hira Amjad
Abstract
Proteolysis is an essential process for the development, growth and even survival of any cell. Genome sequence data can be used to appraise the proteolytic process in different organisms. In this review, the proteases and peptidases of hyperthermophilic archaeon Pyrobaculum calidifontis are examined and summarized using genome sequence data with special focus on proteolysis, and catalytic sites. Proteolytic inventory of P.calidifontis includes energy dependent and independent protease. The energy-dependent proteolysis ensures the degradation of appropriate protein substrate along with time and stress management at the expense of energy. While the energy independent process is also not of less importance in degrading of proteins along with substrate recognition. This can help to establish a relation between different protein substrates and proteases for different processes and to maintain life cycle in P.calidifontis while protecting proteins where high protein denaturation is possible.
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