PJB-2018-842
NEUROPHARMACOLOGICAL EFFECT OF ETHANOLIC EXTRACT OF PERICAMPYLUS GLAUCUS IN BALB/ C MICE
MUHAMMAD KIFAYATULLAH
Abstract
Pericampylus glaucus is one of the largest species of the Menispermaceae that has been used traditionally for the treatment of various neurological disorders since immortal time. Hence, present research aim was to evaluate the neuropharmacological effect of Pericampylus glaucus in Balb/c mice. The ethanolic extract was given orally at dose of 400, 600, 800 mg/kg (b.wt) and diazepam was given i.p at dose of 5 mg/kg (b.wt). The sedative and anxiolytic effect was determined by open field, cages crossing, head dip and sodium pentothal induced sleeping time test, while for the assessment of muscle relaxant and antidepressant activity rotarod and force swimming test was employed. A non significant (P>0.05) in square crossing was noted with the tested drug at a low dose 400 mg/kg (b.wt), while significant (P<0.01) decrease in square crossing was observed at high doses in open field test. The number of cages crossing and head dip was decreased significantly (P<0.001), in ethanolic extract treated groups in the cages crossing and head dip test. Additionally, tested drug caused significant (P<0.001) and dose dependent increase in sleeping time and decrease in onset of sleeping in pentobarbital-induced sleeping test. Ethanolic extract did not show any muscle relaxant effect caused significant (P<0.001) increase in stay time as matched to diazepam. Moreover, Pericampylus glaucus also caused significant (P<0.001) increase in mobility and decrease in immobility time. The result showed positive effect of ethanolic extract and provide the pharmacological justification for this plant.
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