PJB-2018-1023
Phytoxicity, Insecticidal and Antimicrobial studies on methanolic extract of different morphological parts of medicinal plants Dalbergia sisso (Roxb.) and Caralluma tuberculata (N.E.Br)
Ijaz Ali
Abstract
Dalbergia sisso (Roxb.) and Caralluma tuberculata (N.E.Br), are among the valuable flora distributed in various parts of world including Pakistan. These plants are the sources of herbal drugs that have plenty of medicinal uses, reported in folklore as well as in Unani and ethnobotanical medicinal systems. Their anti infective potential has profound importance for the treatment of various infectious conditions. This research was aimed to explore of antimicrobial potential of morphological parts of Leaves, Pods and Bark of Dilbergia sisso (DSL, DSP, DSB respectively) and (CT) Caralluma tuberculata (N.E.Br) these two important plant species. Antimicrobial actions of methanolic extracts of these herbs on bacterial and fungal clinical isolates were studied at 40mg/ml concentration in duplicates. Dimethyl sulfoxide (DMSO) was used as a solvent. Among all methanolic extract, DSL was the most significant extract with broad antimicrobial activity against M. luteus, B. cereus, S. saprophyticus, Proteus sp., Citrobactor, Klebsiella pneumoniae and salmonella typhi (15mm-30mm). DSL, DSP, DSB and CT were found (65% - 80%) against fungal strain. Minimum inhibitory concentrations (MIC) were also significant the B. cereus, Proteus sp., S. saprophyticus and Candida albicans. The MBC of the all methanolic extracts against B. cereus, Proteus sp., S. saprophyticus and Candida albicans ranged between 10mg/ml - 20mg/ml while MFC against Candida albicans was 1.25mg/ml of DSL and 5mg/ml of DSB, DSP and CT. Whereas both plants extracts were not shown significant effect as a insecticidal and phytotoxic agents. This finding can lead to the further exploration of such herbal drugs as potential antimicrobial agent with their complete safety profile.
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