PJB-2019-102
IN VITRO EFFECT OF MEDICINAL PLANTS DRUG (CHWDT) ON BONE LOSS
Muhammad Ali Safder
Abstract
Herbal medicine is going to grow up day by day. As compare to synthetic medicine having less adverse effects. For proving the strength of herbal medicines used different methods including in-vitro assays on animal models. Osteoclasts and osteoblasts, control the amount of bone tissue and regulate bone remodelling. In this study, we studied CHWDT's effectiveness for bone analysis. The treatment of macrophages derived from the nuclear factor linked to nuclear factor (RANKL) macrophages makes the difference of BMM to osteoclasts, as demonstrated by the formation of pits in calcium phosphate-coated plates. However, the osteoclastogenesis hormone RANKL caused by CHWDT therapy was severely suppressed. Our results also show that CHWDT can be a potential treatment agent for deterrence and treating osteoporosis. The HPLC showed the best result in the favour of osteoporosis. The compound Baicalein has the potential for further investigations in drug development.
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