PJB-2019-303
IN VIVO ANTIDIABETIC POTENTIAL OF GLYCIN MAX (SOYBEAN) OIL IN DIABETIC RABBITS
Uroba Ali
Abstract
Diabetes Mellitus (DM) is a major health concern as it has been declared as one out of five main leading causes of death globally. The frequency of diabetes cases has been estimated globally; about 38.2 billion and the number will probably rise to 59.2 billion by 2035. In this research, we investigated the possible role of Glycin max (L) Merr. (Soybean) oil extract as antidiabatic drug in vivo. Diabetes was introduced by intoxicating rabbits with Streptozotocin (STZ). Confirmatory test for the induction of diabetes was performed and animals were medicated with different doses of soybean oil (1g/kg and 2 g/kg) and Metformin HCl (14 mg/kg). Blood samples were collected and analyzed for biochemical analysis. Frequent urination, decreased physical activity and sluggishness were found as compared to controls. In all intoxicated animals, before any treatment blood glucose, cholesterol, triglyceride and LDL level was increased, while the HDL level was observed below the normal range. After treatment for more than two weeks with soybean oil and Metformin HCl, all the parameters were found nearer to normal ranges with respect to the positive control. The conclusion has been drawn from the study is that the soybean oil, shows anti-diabetic activity at a dose of 1 and 2 g/kg. Furthermore, on larger scale, soybean oil should be used to check the anti-diabetic activity, as our results indicate that it could be a natural remedy for type II DM.
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