PJB-2019-395
IN VITRO ANTIBACTERIAL, ANTICANDIDAL ACTIVITY AND QUALITATIVE ESTIMATION OF BIOACTIVE COMPOUNDS IN THE LEAVES OF MEDICINALLY IMPORTANT ACER PENTAPOMICUM
Shehla Khan
Abstract
The significance of plants is well-known to mankind. The kingdom Plantae is a source of various potential drugs. The current research was carried out to assess the phytochemical screening and the anti-bacterial, anticandidal activity of the crude methanolic extract, and its different solvent soluble fractions from the leaves of Acer pentapomicum against different bacterial pathogens and a fungus Candida albicans using disc diffusion susceptibility method. Our results revealed that ethyl acetate and butanol fractions effectively inhibited the growth of all the tested microbes. N-hexane and methanol fractions were also effective against all microbes except Citrobacter freundii. While, chloroform and water extracted samples suppressed the growth of few of the microbes under study. C. freundii was found to be the most resistant bacteria among the tested microbes while, the most susceptible bacterium was found to be E. coli. C albicans was also found to be highly susceptible to all extracted samples of A. pentapomicum. Phytochemical analysis affirmed the presence of various bioactive compounds likeamino acids and proteins, alkaloids, carbohydrates, fats, flavonoids, tannins and saponins and in different extracts of A. pentapomicum leaves.
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