PJB-2019-477
HEPATOPROTECTIVE AND ANTI-INFLAMMATORY ACTIVITIES OF VARIOUS EXTRACTS OF PTERIS VITTATA
Imran Waheed
Abstract
Traditionally Pteris vittata was used as demulcent, hypotensive, tonic, antiviral and antibacterial agent. The purpose of present study was to evaluate hepatoprotective activity of Pteris vittata extracts by CCl₄ induced hepatotoxicity in rats and in-vitro anti-inflammatory activity by using egg albumin denaturation method. Maceration and successive extraction procedures were employed to prepare the n-hexane, chloroform and methanol extracts. Phytochemical screening confirmed that all the three extracts of Pteris vittata contained phytoconstituents such as alkaloids, tannins, glycosides and fats. The biochemical parameters and histopathological studies confirmed that methanol extract of Pteris vittata has shown maximum hepatoprotective activity as compared to other extracts. In in-vitro anti-inflammatory activity, the value of IC50 confirmed that chloroform and n-hexane extract exhibited maximum anti-inflammatory activity when compared to standard drug (diclofenac sodium). Hepatoprotective and anti-inflammatory activity of Pteris vittata was might be due to the presence of phytoconstituents like alkaloids, tannins and glycosides.
To Cite this article:
Download
