PJB-2019-712
BIOLOGICAL INVESTIGATION OF BIOACTIVE COMPOUNDS OF OPUNTIA LITTORALIS ENGELM., IN VITRO
HEBA IBRAHIM ABD EL-MOATY
Abstract
Opuntia littoralis Engelm. (Cactaceae) is wildly growing in Wadi Maged, Mattrouh Governorate, Egypt. Natural products extracted from Cactaceae plants are widely used in folk medicine, food and pharmaceutical field. Accordingly, this study examined the antidiabetic, antimicrobial and cytotoxic activity of plant extracts and estimated total bioactive constituents of this plant for the first time. Antidiabetic and cytotoxic activity were evaluated in vitro using ELISA reader. Antimicrobial activity was achieved using agar methods. The preliminary phytochemical screening of the successive extracts of Opuntia littoralis cladodes and fruits revealed the presence of tannins, carbohydrates and/or glycosides in ethanol, 70% ethanol and water extracts, while the flavonoids were present in ethyl acetate, chloroform, ethanol, 70% ethanol and water extracts. Sterols and/or terpenes were detected in diethyl ether extract. Total flavonoids, terpenes and betalains of O. littoralis cladodes and fruits were determined. Cladode successive extracts had strong antimicrobial activity against some strains of bacteria and fungi. Moreover, fruit juice has a better antimicrobial effect than the fruit ethanolic extract which possessed antidiabetic activity only. The cladode and fruit extracts showed low cytotoxic activity against breast carcinoma cell line (MCF-7).
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