PJB-2019-946
Comparative Evaluation of Current Commercial Antibiotics and Medicinal Plant Extract against Human Pathogenic Bacteria; Pakistan
Anees Ahmad
Abstract
Human pathogenic bacteria have reported resistant to many commercial antibiotics, which led to the emergence of multi drug and extensive drug resistance bacteria, responsible for millions of deaths annually. The need of effective and economical antimicrobial agents has led to search for new sources such as medicinal plant and antimicrobial peptides. In this study, Daphne mucronata and Mallotus philippensis plant extracts were used for antibacterial activity against eight local isolates of human pathogenic bacteria and compared to commercial antibiotics to quantify the effectiveness of the selected medicinal plants extracts. The antibiotic susceptibility test was performed through well diffusion and disc diffusion method. The significant difference was find using PRISM tool applying ANOVA. Our results observed that D. mucronata showed significant activity against some of the selected strains as compared to antibiotics. The highest zones of inhibition of D. mucronata seed extract were recorded against, Providencia stuartii (20mm), B. abortus (19.3mm), Proteus vulgaris (19.3mm), Klebsiella pneumonia (19mm), followed by Pseudomonas aeruginosa (19mm), Enterobacter sakazaki (18.3mm), Escherichia coli (16.6mm) and Staphylococcus aureus (16.6mm). D. mucronata seed extract was reported more significant against B. abortus, E. sakazaki, E. coli and K. pneumonia as compared to Cefepime (8.1mm) and Ciprofloxacin (14.2mm) (p<0.05). However, D. mucronata seed extract showed less significant activity against P. vulgaris, P. stuartii, P. aeruginosa and S. aureus, about similar activity compared to Cefepime (19.3mm) Ciprofloxacin (21mm), Moxifloxacin (21mm) and Ceftriaxone (20mm). On the other hand, M. philippensis showed activity against all selected pathogenic bacteria, but not significant compared to selected antibiotics. It is concluded that the D. mucronata plant has the potential to use as source of new antibiotics to combat against human pathogenic bacteria and can be use as economical and effective source for new antibiotics.
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