PJB-2020-183
Phytochemical and biological studies on Ageratum conyzoides L.
Wahib Noor Khan1
Abstract
Background: The ultrasonic assisted extraction method is more efficient as compared with nor-mal conventional methods by enhancing the rates and extents of mass transfer to and from the interfaces. The current study was aimed to perform ultrasonic assisted extraction of Ageratum conyzoides. Organic organic solvents such as hexane, dichloromethane, ethyl acetate and metha-nol were utilized for the purpose. Results: Phytochemical studies indicated terpenoids, alkaloids, sterols, flavonoids, cardiac gly-cosides, saponins and coumarins as major constituents. The biological potential of various frac-tions was also determined in polar extracts. In antibacterial and antifungal assays, a reasonable activity was obtained. All the extracts were also screened for Leishmanicidal and cytotoxic po-tential against Leishmania major promastigotes and 3T3 cancer cells, respectively. The methanol and ethyl acetate extracts showed significant antileishmanial activities i.e. IC50 5.61 ± 0.50µg/ml and IC50 23.21 ± 0.61µg/ml, respectively. The low percent inhibition of the n-hexane and Ethyl acetate extracts was tested in cytotoxic assay demonstrated the importance of the current plant to use as safe drug in future. Conclusions: The results indicated the terpenoids, alkaloids, coumarins, sterols, flavonoids, cardiac glycosides and saponins as major constituents of plant. A reasonable antibacterial and antifungal potential was exhibited. The low percent inhibition or stimulation of the tested extracts in cytotoxic assay was found
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