PJB-2021-497
Anti-microbial activity of Jordanian plant extracts against Helicobacter pylori
Ahmad S. Alkofahi, Karem H. Alzoubi, Majed M. Masadeh and Zaina Abu Rashed
Abstract
Helicobactor pylori (H. pylori) is a widespread disease. Medicinal plants provided an important source of many products for the eradication and the treatment of H. pylori. The aim of the current study is to assess the efficacy of various fractions from crude extracts of selected plants that grow in Jordan to inhibit the growth of H. pylori strains. The ethanol (95%), water, chloroform, methanol, and hexane fractions of the following plant extracts were tested. Plant extracts were from Artemisia inculata Delile (Asteraceae), Inula viscose (L.) Ait (Asteraceae), Tecoma stans (L.) Kunth ex HBK, Atriplex halimus L., Marrubuim vulgare L and Varthemia iphionoids Boiss (Asteraceae). The antimicrobial efficacy of crude extracts obtained from the above plants were tested in vitro on clinically isolated strains of H. pylori using the disk diffusion method. The minimum inhibitory concentration (MIC) was measured by the serial dilution method. We found that for all the six studied plants, ethanol extracts showed high ability to inhibit the growth of the isolated strains of H. pylori. From the various studied plants, the most effective fractions against the isolated H. pylori strains were the chloroform fraction from A. inculata, and I. viscose and the ethanol extracts from M. vulgare, and T. stans. For V. iphionoids, and A. halimu, the methanol fractions showed highest activity. In conclusion, considering the efficacy of the tested plants in treating several infections due to their antimicrobial properties, Jordanian plants can be used as a raw material for starting the synthesis of new medications against H. pylori.
To Cite this article:
Alkofahi, A.S., K.H. Alzoubi, M.M. Masadeh and Z.A. Rashed. 2023. Anti-microbial activity of Jordanian plant extracts against Helicobacter pylori. Pak. J. Bot., 55(2): DOI: http://dx.doi.org/10.30848/PJB2023-2(3)
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