PJB-2022-250
Evaluation of natural compounds as targeted activators against systemin receptor 160 for defense genes activation in the Solanaceae family
Pravej Alam
Abstract
Plants subjected to injury-causing substances are activating healing and other defense systems. Mechanical damage response involves either local, systemic or both, and consequently, wound signal production, translocation and detection, and transduction to trigger wound-inducible expression of genes. They become an effective target systemin receptor 160 (SR160) for the downstream process to activate the defense genes in the Solanaceae family. In-silico investigations of SR160 protein against natural chemicals have been presented. This study will create and anticipate potential modes of interaction and binding affinities between the natural substances and model SR160 as a 3-dimensional (3D) structure for SR160. The SR160 3D was designed utilizing the SWISS-MODEL system, while the InterBioScreen database provided the compound library. Maestro 10.5 was used for molecular docking. The binding energy ranged from -9.126 kcal to -12.813 mol in all tested compounds. Thus, active commercial defensive gene activators for wound healing can be further synthesized.
To Cite this article:
Alam, P. 2023. Evaluation of natural compounds as targeted activators against systemin receptor 160 for defense genes activation in the Solanaceae family. Pak. J. Bot., 55(5): DOI: http://dx.doi.org/10.30848/PJB2023-5(25)
Download
