PJB-2010-425
BIOLOGICAL SCREENING OF ZIZYPHUS OXYPHYLLA EDGEW LEAVES
MUHAMMAD NISAR*1, WAQAR AHMAD KALEEM2, MUGHAL QAYUM2, ABRAR HUSSAIN4, M. ZIA-UL-HAQ5, IHSAN ALI1 AND M. I. CHOUDHARY3
Abstract
Crude methanolic extract and various fractions of Zizyphus oxyphylla Edgew leaves were screened for antibacterial, antifungal, phytotoxic, cytotoxic and insecticidal activities. Antibacterial bioassay was performed against six bacteria viz., Escherichia coli, Bacillus subtilis, Shigella flexenari, Staphylococcus aureus, Pseudomonas aeruginosa, and Salmonella typhi . Ethyl acetate fraction showed good antibacterial activity against Bacillus subtilus (16mm zone of inhibition) and Staphylococcus aureus (18 mm zone of inhibition). The antifungal activity of these extract performed against 6 fungal strains viz., Trichophyton longifusus, Candida albicans, Aspergilus flavus, Microsporum canis, Fusarium solani and Candida glaberata indicated non significant results. Similarly neither of the fractions showed any cytotoxicity while n-hexane and ethyl acetate fraction showed moderate (40 %) insecticidal activity. All fractions and crude extract showed significant (60-90 %) phytotoxicity.
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