PJB-2011-183
EVALUATION OF ANTIDEPRESSANT-LIKE EFFECTS OF AQUEOUS EXTRACT OF SEA BUCKTHORN (HIPPOPHAE RHAMNOIDES L. SSP. TURKESTANICA) FRUITS IN EXPERIMENTAL MODELS OF DEPRESSION
FARHAT BATOOL1*, AISHA KAMAL1, MADIHA SATTAR1, ASAD HUSSAIN SHAH2, SYED DILNAWAZ AHMED2, ZAFAR SAIED SAIFY3 AND DARAKHSHAN JABEEN HALEEM1
Abstract
Herbs have been used as food and for medicinal purposes for centuries. Research interest has focused on various herbs that possess antidepressant properties and may be useful adjuncts in helping the management of depression in humans. The present study was therefore designed to investigate the antidepressant-like effects of aqueous fruit extract of Sea buckthorn (Hippophae rhamnoides L. ssp. turkestanica) in animal models of depression. In first phase of study test rats were treated with long term oral administration of Sea buckthorn (40 mg/kg P.O.) and controls received an equal volume of fresh water for two weeks. In the second and last phase of study, two groups of animals were exposed to repeated restraint stress (one group from water treated and other group from SBT-FE treated) for next one week All groups of animals were separately submitted to forced swim test (FST), open field test (OFT) and elevated plus maze (EPM) tests for the bio-screening of fruit extract with antidepressant profile. Results revealed that the immobility time in the FST was significantly (p
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