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Pharmacological evaluation of Taverniera nummularia DC.

Yar Muhammad Khan, Saleem Jan, Rahmat Ali Khan, Zabta Khan Shinwari, Faizan Ullah, Hizb Ullah and Sultan Mehmood

The current study was focused on the phytochemical investigation and pharmacological activities of the various solvent fractions (methanolic, n-hexane, dichloromethane, ethyl acetate and water) of Taverniera nummularia (T. nummularia). The various solvent fractions were screened for phytochemicals, antibacterial assay, antifungal assay, DPPH (1, 1-diphenyl-2-picrylhydrazyl) free radical scavenging assay, hydrogen peroxide scavenging assay and reactive oxygen species (ROS) detoxification effects on human blood lymphocytes under H2O2 induced stress. Methanolic extract of T. nummularia showed significantly higher antibacterial activity against S. aureus as compared to other fractions (p<0.05). The ethyl acetate, n-hexane and chloroform fractions exhibited significantly higher antibacterial activity against P. aeruginosa. The ranking of various fractions for antibacterial activity against E. coli was methanolic = ethyl acetate = aqueous > n-hexane = chloroform. Maximum antifungal activity against Aspergillus fumigates (59.25%), Aspergillus flavus (62.02%) and Aspergillus niger (64%) was shown by chloroform fraction. Antioxidant activity was higher for n-hexane, aqueous, methanolic and ethyl acetate fractions. The superoxide dismutase (SOD), catalase (CAT) and peroxidase (POD) activities of the human blood lymphocytes were significantly decreased under H2O2 induced oxidative stress (p<0.05). The activities of the antioxidant enzymes were significantly improved by the various leaf fractions of T. nummularia at 50 µg/ml under H2O2 stress; methanol and aqueous fractions being the most effective ones. The increase in antioxidant enzymes activities resulted in a significant decrease in the level of reactive oxygen species (ROS) and thiobarbituric acid (TBARS) content

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