PJB-2019-53
Evaluation of biological potential and physico-chemical properties of Acridocarpus orientalis (Malpighiaceae)
Najeeb Ur Rehman, Fazal Mabood, Abdul Latif Khan, Liaqat Ali, Syed Abdullah Gillani, Ghulam Abbas, Ajmal Khan, Ahmed Al-Harrasi and Javid Hussain
Abstract
Acridocarpus orientalis, an arid land plant and famous in Arabian region for medicinal values, has been investigated for its biological and ecological role in the current study. The methanol (JAOMF) extract of stem and leaves of A. orientalis along with various fractions (n-hexane; JAOHF, chloroform; JAOCF, ethyl acetate; JAOEF, n-butanol; JAOBF, and aqueous; JAOWF) were tested for allelopathic, cytotoxic, anti-fungal, antioxidant and enzyme inhibition activities. In case of allelopathic potential, the higher concentration (100 mg) of dried leaves and stem were significantly suppressing the lettuce seed germination as compared to control. Among various fractions, n-butanol and chloroform have inhibited the radical and hypocotyl growths of lettuce seeds in a dose-dependent manner. The fractions showed a week growth inhibitory effects against Chitomium globosum, Fusarium oxysporum, and Aspergillus niger. Total flavonoid contents were significantly higher in ethyl acetate (279.85 μg/g of dry extract) and n-butanol (142.22 μg/g of dry extract) fractions of stem while n-hexane (77.6 μg/g of dry extract) fraction of leaves showed higher flavonoid contents. Total phenolic contents were found higher in the ethyl acetate fraction of stem (16.8 mg/g of dry weight) followed by n-butanol (10.6 mg/g of dry weight). Aqueous fraction of leaves showed significantly higher anti-lipid peroxidation (60.6%) activity followed by chloroform (49.9%). Higher concentration of chloroform fraction of stem expressed higher cytotoxic effects for adenocarcinoma and hepatoma cancer cell lines as compared to other fractions.
To Cite this article:
N.U. Rehman, F. Mabood, A.L. Khan, L. Ali, S.A. Gillani, G. Abbas, A. Khan, A. Al-Harrasi and J. Hussain. 2019. Evaluation of biological potential and physico-chemical properties of Acridocarpus orientalis (Malpighiaceae). Pak. J. Bot., 51(3): DOI: http://dx.doi.org/10.30848/PJB2019-3(8)
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